Saiz LC, Gorricho J, Garjon J, Celaya MC, Muruzabal L, Malon MDM, Montoya R, Lopez A. Blood pressure targets for the treatment of people with hypertension and cardiovascular disease. Cochrane Database of Systematic Reviews 2017, Issue 10. Art. No.: CD010315. DOI: 10.1002/14651858.CD010315.pub2.
No evidence of a difference in total mortality and serious adverse events was found between treating to a lower or to a standard blood pressure target in people with hypertension and cardiovascular disease. This suggests no net health benefit from a lower systolic blood pressure target despite the small absolute reduction in total cardiovascular serious adverse events. There was very limited evidence on adverse events, which lead to high uncertainty. At present there is insufficient evidence to justify lower blood pressure targets (less than or equal to 135/85 mmHg) in people with hypertension and established cardiovascuclar disease. More trials are needed to answer this question.