Pharmacotherapy for hypertension in adults aged 18 to 59 years

Pharmacotherapy for hypertension in adults aged 18 to 59 years

Musini VMGueyffier FPuil LSalzwedel DMPharmacotherapy for hypertension in adults aged 18 to 59 yearsCochrane Database of Systematic Reviews 2017, Issue 8. Art. No.: CD008276. DOI: 10.1002/14651858.CD008276.pub2.

Antihypertensive drugs used to treat predominantly healthy adults aged 18 to 59 years with mild to moderate primary hypertension have a small absolute effect to reduce cardiovascular mortality and morbidity primarily due to reduction in cerebrovascular mortality and morbidity. All-cause mortality and coronary heart disease were not reduced.  There is a lack of good evidence on withdrawal due to adverse events. Future trials in this age group should be at least 10 years in duration and should compare different first-line drug classes and strategies.